standard_cest_protocols
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standard_cest_protocols [2020/11/10 17:28] mzaiss |
standard_cest_protocols [2021/10/11 13:22] |
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| - | ====== Standard CEST protocols ====== | ||
| - | |||
| - | We want to hint that there is a more detailed and growing site for standard protocols based on pulseq here | ||
| - | [[https:// | ||
| - | |||
| - | We recommend to follow this site in the future for standardization of protocols. | ||
| - | |||
| - | |||
| - | below you find the old information, | ||
| - | |||
| - | ---- | ||
| - | B1 definitions here are the flip angle equivalent (pure FA), thus the average B1 of a **single** saturation pulse. | ||
| - | This also means that the flip angle of each saturation pulse is directly given by FA = B1·γ·t_p | ||
| - | |||
| - | t_p = duration of a single saturation pulse, | ||
| - | t_sat = total time of the saturation pulse train | ||
| - | |||
| - | |||
| - | ---- | ||
| - | |||
| - | ===== 3T APT ===== | ||
| - | |||
| - | ====APTw_1 : APT-weighted, | ||
| - | * pulse shape = Gaussian | ||
| - | * B1 = 2.22 µT | ||
| - | * n = 20 | ||
| - | * t_p = 50 ms | ||
| - | * t_d = 40 ms | ||
| - | * => DC = 0.55 and t_sat = n*(t_p+t_d) = 1.8 s | ||
| - | * T_rec = 2.4/12 s (saturated/ | ||
| - | |||
| - | total acquisition time (depends on the readout) : approximately 3min24s for snapshot-GRE | ||
| - | |||
| - | |||
| - | ====APTw_2 | ||
| - | |||
| - | * pulse shape = RECT | ||
| - | * B1 = 2 µT | ||
| - | * n = 5 | ||
| - | * t_p = 100 ms | ||
| - | * t_d = 72 ms | ||
| - | * => DC = 0.58 and t_sat = n*(t_p+t_d) = 860 ms | ||
| - | * T_rec = 2 s | ||
| - | * measurements= 17 | ||
| - | |||
| - | Δω [ppm] = -300, 4, -3.75, -3.75, -3.5, -3.5, -3.25, -3.25, -3, 3, 3.25, 3.25, 3.5, 3.5 3.75, 3.75, 4 | ||
| - | |||
| - | ====APTw_3 : APT-weighted, | ||
| - | |||
| - | * pulse shape = RECT | ||
| - | * B1 = 2 µT | ||
| - | * n = 8 | ||
| - | * t_p = 100 ms | ||
| - | * t_d = 5 ms | ||
| - | * => DC = 0.95 and t_sat = n*(t_p+t_d) = 840 ms | ||
| - | * T_rec = 2 s | ||
| - | * measurements= 17 | ||
| - | |||
| - | Δω [ppm] = -300, 4, -3.75, -3.75, -3.5, -3.5, -3.25, -3.25, -3, 3, 3.25, 3.25, 3.5, 3.5 3.75, 3.75, 4 | ||
| - | |||
| - | |||
| - | |||
| - | |||
| - | ---- | ||
| - | |||
| - | |||
| - | ===== 3T Multi-Pool (MP) - low power - selective amide and NOE protocols ===== | ||
| - | |||
| - | |||
| - | ==== MP_1 : low DC (//GLINT//) ==== | ||
| - | |||
| - | * pulse shape = Gaussian | ||
| - | * B1 = 0.6 µT (first scan), | ||
| - | * n = 80 | ||
| - | * t_p = 20.48 ms | ||
| - | * t_d = 20 ms | ||
| - | * => DC = 0.5 and t_sat = n*(t_p+t_d) = 3.2 s | ||
| - | * T_rec = 0 ms | ||
| - | * measurements = 54 | ||
| - | |||
| - | Δω [ppm] = [ -300, -100, -50, -40, -30, -20, -10, -9.5, -9, | ||
| - | |||
| - | total acquisition time (depends on the readout) : approximately 5min20s for snapshot-GRE | ||
| - | |||
| - | ==== MP_2 : high DC (//HD//) ==== | ||
| - | |||
| - | * pulse shape = Gaussian | ||
| - | * B1 = 0.6 µT (first scan), | ||
| - | * n = 148 | ||
| - | * t_p = 20 ms | ||
| - | * t_d = 5 ms | ||
| - | * => DC = 0.8 and t_sat = n*(t_p+t_d) = 3.7 s | ||
| - | * T_rec = 0/12 s (saturated/ | ||
| - | * measurements = 57 | ||
| - | |||
| - | Δω [ppm] = 250, 200, 150, 110, 80, 60, 45, 35, 28, 22, 17, 13, 10, 7.5, 6, 5, 4.5, 4, 3.5, 3, 2.5, 2, 1.5, 1.2, 0.9, 0.7, 0.5, 0.3, 0, −0.3, −0.5, −0.7, −0.9, −1.2, −1.5, −2, −2.5, −3, −3.5, −4, −4.5, −5, −6, −7.5, −10, −13, −17, −22, −28, −35, −45, −60, −80, −110, −150, −200, −250 | ||
| - | |||
| - | total acquisition time (depends on the readout) : approximately 7min34s per B1 for snapshot-GRE | ||
| - | |||
| - | |||
| - | ===== 7T Multi-Pool (MP) - low power - selective amide and NOE protocols ===== | ||
| - | |||
| - | ==== MP_1 (//GUFI TH2//) ==== | ||
| - | |||
| - | * pulse shape = Gaussian | ||
| - | * B1 = 0.6 µT (first scan), | ||
| - | * n = 120 | ||
| - | * t_p = 15ms | ||
| - | * t_d = 10 ms | ||
| - | * => DC = 0.6 and t_sat = n*(t_p+t_d) = 3.0 s | ||
| - | * T_rec = 0/12 s (saturated/ | ||
| - | * measurements = 56 | ||
| - | |||
| - | Δω [ppm] = [-300 | ||
| - | -100 | ||
| - | -50 | ||
| - | -20 | ||
| - | -12 | ||
| - | -9 | ||
| - | -7.25 | ||
| - | -6.25 | ||
| - | -5.5 | ||
| - | -4.7 | ||
| - | -4 | ||
| - | -3.3 | ||
| - | -2.7 | ||
| - | -2 | ||
| - | -1.7 | ||
| - | -1.5 | ||
| - | -1.1 | ||
| - | -0.9 | ||
| - | -0.6 | ||
| - | -0.4 | ||
| - | 0 | ||
| - | 0.4 | ||
| - | 0.6 | ||
| - | 0.95 | ||
| - | 1.1 | ||
| - | 1.25 | ||
| - | 1.4 | ||
| - | 1.55 | ||
| - | 1.7 | ||
| - | 1.85 | ||
| - | 2 | ||
| - | 2.15 | ||
| - | 2.3 | ||
| - | 2.45 | ||
| - | 2.6 | ||
| - | 2.75 | ||
| - | 2.9 | ||
| - | 3.05 | ||
| - | 3.2 | ||
| - | 3.35 | ||
| - | 3.5 | ||
| - | 3.65 | ||
| - | 3.8 | ||
| - | 3.95 | ||
| - | 4.1 | ||
| - | 4.25 | ||
| - | 4.4 | ||
| - | 4.7 | ||
| - | 5.25 | ||
| - | 6.25 | ||
| - | 8 | ||
| - | 12 | ||
| - | 20 | ||
| - | 50 | ||
| - | 100 | ||
| - | -300 | ||
| - | ] | ||
| - | |||
| - | |||
| - | total acquisition time (depends on the readout) : approximately 6:40s per B1 for snapshot-GRE | ||
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standard_cest_protocols.txt · Last modified: 2021/10/11 13:22 (external edit)
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