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====== Bloch-McConnell Simulation & Fit ======
{{ :bm.png?direct&250|}}

Here you find a Bloch-McConnell simulation introduced in the publications 
  * **Schmitt et al. (2011), MRM 65: 1620–1629. [[http://onlinelibrary.wiley.com/doi/10.1002/mrm.22750/full|DOI: 10.1002/mrm.22750]]**, 
  * **Roeloffs et al. (2014), NMR Biomed., 28, 40–53 [[http://onlinelibrary.wiley.com/doi/10.1002/nbm.3192/full|doi: 10.1002/nbm.3192]]**
  * **Zaiss et al. (2014), NMR Biomed., 28; 217–230 [[http://onlinelibrary.wiley.com/doi/10.1002/nbm.3237/abstract|doi: 10.1002/nbm.3237]]**, 
  * **Meissner et al. (2015), NMR Biomed., 28, 1196–1208. [[http://onlinelibrary.wiley.com/doi/10.1002/nbm.3362/abstract|doi: 10.1002/nbm.3362]]**, 
It was initially based on the code provided by Shanrong Zhang published in [[http://onlinelibrary.wiley.com/doi/10.1002/mrm.20408/abstract|Woessner, Zhang, Merritt and Sherry: Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI, MRM 2005]]. It was extended for multiple pools, including semi-solid MT, and also extended for pulsed RF saturation.
 
Dowload zipped Matlab implementations [[https://github.com/cest-sources/BM_sim_fit/archive/master.zip|here]] or find the package on [[https://github.com/cest-sources/BM_sim_fit/]]

======  Tutorial ======


===== Bloch McConnell simulation multi-Z-spectra fit =====
{{youtube>O_DChxR023s?500x360|Tutorial: BM sim fit}}


This code allows for simulation of BM system upon RF presaturation 
  * multiple pools possible (water, 5 CEST, 1  semisolid MT)
  * trains RF pulses with arbitratry pulse shapes possible (gauss, sinc, spin-lock already implemented)
  * both analytical (if possible) and full numerical simulation possible
  * transient and steady-state possible
  * first order readout schemes possible
  * Both full Z-spectra and single offset evaluation possible
  * Ready for multi parameter simulations
 
**Read more about usage on github in
[[https://github.com/cest-sources/BM_sim_fit/|BM_Documentation.docx and BM_tutorial.pptx]]**

=====Acknowledgments=====
This code was created by Moritz Zaiss based on the cw BM simulation and fit code of Shanrong Zhang. A revised version was created with the help of Patrick Schuenke, Christian Meyer, Christian David and Volkert Roeloffs.



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